Title: Process for obtaining L-dihydroorotic acid and use thereof
Application Number: 98812046 Application Date: 1998.12.08
Publication Number: 1281550 Publication Date: 2001.01.24
Approval Pub. Date: 2006.01.18 Granted Pub. Date: 2006.01.18
International Classifi-cation: G01N30/02;B01J41/20;B01D15/08;C07D239/22
Applicant(s) Name: Hoechst Marion Roussel Deutschland GmbH Address:
Inventor(s) Name: U. Milbert;R. Bartlett;E. Ruuth
Attorney & Agent: huang gesheng
Abstract:
    The invention relates to a process for obtaining L-dihydroorotic acid by chromatography on an anionic exchange material in a base water mixture under a pressure from about 1.1 MPa to about 40 MPa. The process can be used to investigate the in vitro and in vivo activity of N-(4-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide, N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrontonamide and similar compounds.
Time: 10
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