Title: Method for increasing hemoprotein production in filamentous fungi
Application Number: 97195373 Application Date: 1997.06.09
Publication Number: 1221453 Publication Date: 1999.06.30
Approval Pub. Date: 2006.08.02 Granted Pub. Date: 2006.08.02
International Classifi-cation: C12N15/31;C12N15/53;C12N15/60;C07K14/795;C12N9/02;C12N9/08;C12N1/15;C12N9/88;C12N9/10;C12N15/80;C12R
Applicant(s) Name: Novo Nordisk Biotech Inc. Address:
Inventor(s) Name: S. L. Elrod;J. R. Cherry;A. Jones
Attorney & Agent: huang gesheng
Abstract:
    The present invention relates to methods of producing hemoproteins comprising (a) introducing into a filamentous fungal cell, which is capable of producing the hemoprotein, (i) one or more first control sequences capable of directing the expression of a heme biosynthetic enzyme encoded by a first nucleic acid sequence endogenous to the filamentous fungal cell, wherein the one or more of the first control sequences are operably linked to the first nucleic acid sequence; and/or (ii) one or more copies of one or more second nucleic acid sequences encoding a heme biosynthetic enzyme; (b) cultivating the filamentous fungal cell in a nutrient medium suitable for production of the hemoprotein and the heme biosynthetic enzymes; and (c) recovering the hemoprotein from the nutrient medium of the filamentous fungal cell.
Time: 3
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