Title: Method for producing l-lysine
Application Number: 03133131 Application Date: 1997.12.05
Publication Number: 1524956 Publication Date: 2004.09.01
Approval Pub. Date: 2006.09.06 Granted Pub. Date: 2006.09.06
International Classifi-cation: C12N15/11,C12R1/15,C12R1/13,C12N15/63
Applicant(s) Name: Ajinomoto KK Address:
Inventor(s) Name: Sugimoto Masakazu, Araki Masayuki, Nakamatsu Tsuyo
Attorney & Agent: liu dong
Abstract:
     A coryneform bacterium harboring an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized, and comprising an enhanced DNA sequence coding for a dihydrodipicolinate reductase, an enhanced DNA sequence coding for dihydropicolinate reductase, an enhance DNA sequence coding for dihydropicolinate synthase, an enhanced DNA sequence coding for diaminopimelate decarboxylase and an enhanced DNA sequence coding for aspartate aminotransferase; a method for producing L-lysine comprising the steps of cultivating the coryneform bacterium in an appropriate medium to allow L-lysine to be produced and accumulated in a culture of the bacterium, and collecting L-lysine from the culture; and a recombinant DNA usable for production of the coryneform bacterium.
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