Title: Natural antitumor or antiviral substances and use of the same
Application Number: 200410078967 Application Date: 1998.06.02
Publication Number: 1616671 Publication Date: 2005.05.18
Approval Pub. Date: 2006.12.27 Granted Pub. Date: 2006.12.27
International Classifi-cation: C12P19/40;C12R1/91;A61P31/12;A61P35/00
Applicant(s) Name: Tsuneatu Mori Address:
Inventor(s) Name: Tsuneatu Mori;Maowu Guo;Etsuko Mori
Attorney & Agent: chen cuan
Abstract:
    The present invention relates to substances having an efficacy against tumors and viruses on which the conventional anti-tumor agents and anti-virus agents exhibit only insufficient effects, and having carcinostatic effect and anti-virus effect on various resistant tumors as well as a reduced side effect such that normal human cells will not be impaired. The present invention relates to an anti-tumor or anti-viral substance represented by the formula(1)wherein R1 represents a nucleic acid base represented by a specific formula, and R2 represents a hydrogen atom, a hydroxy group or a methoxy group, or a pharmaceutically acceptable salt thereof. The present invention also relates to a process for preparing the substance represented by the formula(1)or a pharmaceutically acceptable salt thereof, wherein NS cell which has the ability of producing the compound represented by the formula(1)is cultured, the compound represented by the formula(1)are harvested from the culture liquid, and if necessary the compound is converted into a pharmaceutically acceptable salt thereof. Furthermore, there are also disclosed a pharmaceutical comprising the above described compound as an effective ingredient, and CD57-positive, HLA.DR-strongly positive human type natural suppressor cell.
Time: 3