Title: Genetically modified tumor-targeted bacteria with reduced virulence
Application Number: 98811030 Application Date: 1998.09.09
Publication Number: 1278864 Publication Date: 2001.01.03
Approval Pub. Date: 2006.04.26 Granted Pub. Date: 2006.04.26
International Classifi-cation: C12N1/20;A61K38/14;A61K39/112;C12N15/09;A61P35/00;A01N37/18;C12R1/42
Applicant(s) Name: Vion Pharmaceuticals, Inc. Address:
Inventor(s) Name: D. Bermudes;K. B. Low;M. Ittensohn
Attorney & Agent: zhang anyu
Abstract:
    The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The invention is also directed to Salmonella sp. containing a genetically modified msbB gene as well as a genetic modification in a biosynthetic pathway gene such as the purI gene. The present invention further relates to the therapeutic use of the mutant $I(Salmonella) for growth inhibition and/or reduction in volume of solid tumors.
Time: 9