Title: Microbe process for preparing (4R, 6R)-4-hydroxyl-2,2,6-trimethyl cyclohexanone
Application Number: 99117983 Application Date: 1999.08.18
Publication Number: 1254760 Publication Date: 2000.05.31
Approval Pub. Date: 2006.03.22 Granted Pub. Date: 2006.03.22
International Classifi-cation: C12P7/26;C12R1/01
Applicant(s) Name: F. Hoffmann-La Roche AG. Address:
Inventor(s) Name: Kiyomizu Eiya;Nigita Taira
Attorney & Agent: huang yifen
Abstract:
    A process for making (4R, 6R)-4-hydroxy-2,2,6-trimethylcyclohexanone by contacting (6R)-2,2,6-trimethylcyclohexanedione with a microorganism which is selected from microorganisms of the genera Cellulomonas, Corynebacterium, Planococcus and Arthrobacter and which is capable of the selective asymmetric reduction of (6R)-2,2,6-trimethylcyclohexanedione to (4R, 6R)-4-hydroxy-2,2,6-trimethylcyclohexanone, and recovering the resulting (4R, 6R)-4-hydroxy-2,2,6-trimethylcyclohexanone from the reaction mixture. The selective asymmetric reduction can be effected in the presence of a co-factor, such as, nicotinamide adenine dinucleotide (NAD), nicotinamide adenine dinucleotide phosphate (NADP), or said co-factor with glucose and glucose dehydrogenase (GDH), and/or in the presence of a surfactant. The product is useful for the synthesis of carotenoids, such as, zeaxanthin.
Time: 4