Title: Process for producing HMG-CoA reductase inhibitors
Application Number: 00805212 Application Date: 2000.01.20
Publication Number: 1344328 Publication Date: 2002.04.10
Approval Pub. Date: 2006.02.08 Granted Pub. Date: 2006.02.08
International Classifi-cation: C12P7/62;C12P17/06;C12R1/32;C12R1/15;C12R1/13;C12R1/01;C12R1/06;C12R1/265;C12R1/34
Applicant(s) Name: Kyowa Hakko Kogyo Co Ltd Address:
Inventor(s) Name: Hashimoto Shin-ichi;Yonetani Yoshiyuki;Ozaki Akio
Attorney & Agent: cao wen
Abstract:
    A process for producing compounds (II-a) or compounds (II-b), which are respectively hydroxylated products of compounds represented by general formula (I-a) (here in after referred to as the compounds (I-a)) or closed lactone derivatives thereof (hereinafter referred to as the compounds (I-b)). This process is characterized by treating in an aqueous medium the compounds (I-a) or (I-b) with an enzyme source comprising a microorganism having an activity of hydroxylating the compounds (I-a) or (I-b), having no sporulability and showing no hyphal growth, or an optionally processed culture of the microorganism and collecting the compounds (II-a) or (II-b) from the aqueous medium. In formula (I-a) R
Time: 5