Title: Methods for producing polypeptides in fungal cells
Application Number: 00804506 Application Date: 2000.02.02
Publication Number: 1342204 Publication Date: 2002.03.27
Approval Pub. Date: 2006.08.09 Granted Pub. Date: 2006.08.09
International Classifi-cation: C12N15/31;C12N15/57;C12N15/80;C12N15/01;C12N9/62;C12N1/15;C07K14/38;C12P21/02;C12R1/66;C12R1/19
Applicant(s) Name: Novo Nordisk Biotech Inc. Address:
Inventor(s) Name: D.S. Yaver
Attorney & Agent: fan weimin
Abstract:
    The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a mutant of a parent fungal cell under conditions conducive for the production of the polypeptide, wherein the mutant cell comprises a first nucleic acid sequence comprising a modification of one or more genes of a pacC pH signal transduction pathway or homologues thereof, and a second nucleic acid sequence encoding the polypeptide; and (b) isolating the polypeptide from the cultivation medium.
Time: 8
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