Title: Forms of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase
Application Number: 01821215 Application Date: 2001.10.20
Publication Number: 1578836 Publication Date: 2005.02.09
Approval Pub. Date: 2006.12.06 Granted Pub. Date: 2006.12.06
International Classifi-cation: C12N15/53,C12N9/04,C12Q1/32,C12Q1/54,C12R1/01
Applicant(s) Name: Hoffmann La Roche Address:
Inventor(s) Name: Kratzsch Peter, Schmuck Rainer, Beck Daniela, Shao
Attorney & Agent: zhang anyu
Abstract:
     The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH), to genes encoding mutated s-GDH, to mutant proteins of s-GDH with improved substrate specificity for glucose, and to different applications of these s-GDH variants, particularly for determining concentrations of sugar, especially of glucose in a sample.
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