Title: Prodn. and use of porphyrins
Application Number: 90104921 Application Date: 1990.06.11
Publication Number: 1057194 Publication Date: 1991.12.25
Approval Pub. Date: Granted Pub. Date: 1998.07.29
International Classifi-cation: A61K31/41,C12P17/18,C12Q1/02
Applicant(s) Name: FMC Corp. Address:
Inventor(s) Name: Blaik Phillip Halling
Attorney & Agent: QUAN GYONGLIU
Abstract:
     Disclosed here is a method and a pharmaceutical comp osition for killing mammalian tumor cells by subjecting said cells to light in the presence of a light-activatable tetrapyrrole, in which the improvement comprises treating said cells with a compound which inhibits the enzymatic conversion of proteporphyrinogen to protoporphyrin IX in said cells thereby causing a build up protoporphyrin IX in said cells. Also disclosed in a method for the prod. of protoporphyrin IX which comprises growing cukaryotic microalgae in the presence of a protoporphyrinogen oxidase inhibitor.
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