Title: PTP-D subfamily of protein tyrosine phosphatases
Application Number: 93117790 Application Date: 1993.08.05
Publication Number: 1091139 Publication Date: 1994.08.24
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K37/02;A61K37/54;C07K15/04;C07K15/12;C07K15/14;C12N9/50;C12N15/09;C12P21/02;C12Q1/37;C12Q1/68;G01
Applicant(s) Name: Max-Planck-Gesellschaft zur Foerderung der Wissens Address:
Inventor(s) Name: Axel Ullrich;Niels Peter Hundahl Moller;Karin Bach
Attorney & Agent: WANG YANG
Abstract:
    A novel subfamily (PTP-D) of protein tyrosine phosphatases is identified. Included in this family are PTP-D proteins or glycoproteins having one, two, or three identified amino acid changes in previously defined consensus sequences in the catalytic phosphatase domains of known protein tyrosine phosphatases. The PTP-D proteins or glycoproteins may be produced by recombinant means. Antibodies to PTP-D proteins or glycoproteins and nucleic acid constructs coding therefor, and methods for screening molecules which can bind to PTP-D proteins or glycoproteins and inhibit or stimulate their enzymatic activity, are provided.
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