Title: Human monoclonal antibodies to serotypic lipopolysaccharide determinants on gram-negative bacteria and their production
Application Number: 85104643 Application Date: 1985.06.15
Publication Number: 1005616 Publication Date: 1986.12.10
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K39/40,C12N5/00
Applicant(s) Name: Genetic Systems Corp. (US) 3005 First Avenue, Seat Address:
Inventor(s) Name: Anthony W. Siadak
Attorney & Agent: JIANG JIANCHENG YANG HOUCHANG
Abstract:
     Transformed human lymphocyte cell lines have been produced which secrete human monoclonal antibodies to serotypic determinants on LPS molecules of gram-negative bacteria. These antibodies have been found to be protective against lethal challenges of the homologous bacteria. Pharmaceutical compositions containing these antibodies and their prophylactic and therapeutic use in the management of gram-negative disease in humans are also disclosed. Human lymphocyte cell lines secreting human monoclonal antibodies specifically reacting with Pseudomonas aeruginosa Fisher immunotypes 1 (C5B7), 2 (6F11), 4 C5D5), 5 (13C1), 6 (5G2) and 7 (8E7) were deposited at the American Type Culture Collection and given A.T.C.C. Accession Nos. CRL 8753, CRL 8562, CRL 8754, CRL 8796, CRL 8797 and CRL and CRL 8795, respectively.
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