Title: Recombinant DNA and use thereof
Application Number: 85107120 Application Date: 1985.09.21
Publication Number: 1009927 Publication Date: 1987.04.01
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K39/29,C12N1/18,C12N15/00
Applicant(s) Name: Takeda Chemical Industries, Ltd. (JP) Osaka 541, J Address:
Inventor(s) Name: Masakazu Kikuchi
Attorney & Agent: LUO HONG LIU YUANJIN
Abstract:
     HBsAg can be produced by cultivating yeast containing a recombinant DNA wherein a DNA in which a sequence complementary with the 3' end of 18S ribosomal RNA is added upstream of a DNA coding for hepatit is B virus surface antigen is bound just after a sequence complementary with the 3' end of 18S ribosomal RNA located at the 5' non-coding region of yeast repressible acid phosphatase gene. HBsAg thus obtained can be used as a vaccine to prevent HBV infection.
Time: 5
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