Title: Vectors and methods for expression of human protein C activity
Application Number: 86100868 Application Date: 1986.02.07
Publication Number: 1003499 Publication Date: 1986.09.24
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: C12N15/00
Applicant(s) Name: Eli Lilly And Company (US) Lilly Corporate Center, Address:
Inventor(s) Name: Nils Ulrik Bang; Robert John Beckmann; Stanley Ric
Attorney & Agent: WU XIAONAN
Abstract:
    The present invention comprises novel DNA compounds which encode human protein C activity. A variety of eukaryotic and prokaryotic recombinant DNA expression vectors have been constructed that comprise the novel protein C activity-encoding DNA and drive expression of protein C activity when transformed into an appropriate host cell. The novel expression vectors can be used to produce protein C derivatives, such as non-carboxylated, non-glycosylated, or non-hydroxylated protein C, and to produce protein C precursors, such as nascent or zymogen protein C, and to produce sub-fragments of protein C, such as active or inactive light and heavy chain. The recombinant-produced protein C activity is useful in the treatment and prevention of a variety of vascular disorders.
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