Title: Production method for interleukin-2
Application Number: 86101353 Application Date: 1986.03.10
Publication Number: 1003095 Publication Date: 1986.09.10
Approval Pub. Date: 1990.11.07 Granted Pub. Date: 1990.11.07
International Classifi-cation: A61K37/02;C12N15/09;C12P21/02
Applicant(s) Name: Takeda Chemical Industries Ltd. Address:
Inventor(s) Name: Kazuaki Kitano;Shigeru Fujimoto
Attorney & Agent: XIN MINZHONG GU BAIDI
Abstract:
    The present invention provides an improvement in a method for producing interleukin-2 by cultivating a transformant of Escherichia coli capable of producing interleukin-2 into a medium, which comprises inoculating said Escherichia coli into the medium of pH from about 4.8 to 6.0 and growing it while maintaining this pH range. By the method of the present invention, the interleukin-2 productivity is considerably improved.
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