Title: Method of controlling culture and apparatus therefor
Application Number: 86101928 Application Date: 1986.03.25
Publication Number: 1003497 Publication Date: 1986.09.24
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: C12M1/36,C12N1/00
Applicant(s) Name: Hitachi Ltd. Address:
Inventor(s) Name: Nobuko Nishimura, Norio Shimizu, Shinichi fukuzono
Attorney & Agent: GU BAIDI XIN MINZHONG
Abstract:
     A method of controlling culture wherein cells are aerobically cultured to produce metabolite is characterized by adding substrate and/or inducer to the culture broth, judging the endpoint of the growth of the cells and/or the production of the metabolite or terminating the culture under the guidance of a change in the ratio of the first parameter based on the amount of carbon dioxide evolved by the cell culture to the second parameter based on the amount of oxygen consumed by the cell culture. The ratio is a respiratory quotient, for instance.
Time: 5