Title: Process for producing 10-hydroxy camptothecine by biotransformation
Application Number: 85100520 Application Date: 1985.04.01
Publication Number: 1002314 Publication Date: 1986.08.13
Approval Pub. Date: Granted Pub. Date: 1991.12.11
International Classifi-cation: C12P17/18
Applicant(s) Name: Shanghai Inst. of Medicine, Chinese Academy of Sci Address:
Inventor(s) Name:
Attorney & Agent: FEI KAIDA
Abstract:
     This invention utilizes non-toxic yellow aspergillus T-419 to convert xishu alkaloid which exists in xishu tree in high content, into 10-alkyl xishu alkaloid biologically with conversion greater than 50%. This invention applies new separation technology with inert large pore resin. By adsorbing converted 10-alkyl xishu alkaloid on large pore resin and chromatographing, the finished product can meet medicine specifications, its recovery is 50%. The advantage of producing 10-alkyl xishu alkaloid by this invention over the original method is expanded resources and saving on raw materials.
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