Title: Process for minactivin and its use
Application Number: 85107267 Application Date: 1985.09.28
Publication Number: 1010133 Publication Date: 1987.04.08
Approval Pub. Date: Granted Pub. Date: 1994.07.20
International Classifi-cation: A61K37/47,A61K37/64,C12P21/00,C12Q1/56
Applicant(s) Name: Biotechnology Australia PTY Ltd. Address:
Inventor(s) Name:
Attorney & Agent: LU XINHUA
Abstract:
     Minactivin, a protein inactivator of urokinase-type plasminogen activator, has been shown to be a natural inactivator of this plasminogen activator which is associated with invasive tumours, and is therefore indicated as a crucial element in the body's normal defense against tumour invasion and metastasis. It may be produced by the cultiation of minactivin-producing cells in vitro, and recovery of the cell culture supernatant. By controlling the culture conditions, the protein minactivin may be produced in a partially purified form which may be used for diagnosis and treatment of tumours.
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