Title: Improved process for producing A-21978C derivative
Application Number: 85107552 Application Date: 1985.10.08
Publication Number: 1011094 Publication Date: 1987.05.20
Approval Pub. Date: 1992.04.01 Granted Pub. Date: 1992.04.01
International Classifi-cation: A61K37/02;C12P21/04
Applicant(s) Name: Elililly and Co. Address:
Inventor(s) Name: Floyd Milton Huber
Attorney & Agent: CAO HENGXING
Abstract:
    An improved process is provided for producing A-21978C cyclic peptide derivatives having a C2-C14 alkonoyl side chain which comprises feeding a C2-C14 alkanoic acid, or an ester or salt thereof, to the A-21978C-producing culture during the production stages of the fermentation. In addition, a new process is provided for producing the A-21978C antibiotics which comprises cultivating under aerobic conditions a new strain of microorganism.
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