Title: Process for the preparation of arylolycidyl ethers and 3-substituted 1-alkylamino-2-propanols
Application Number: 86102227 Application Date: 1986.02.13
Publication Number: 1008340 Publication Date: 1987.02.04
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: C12P13/00;C12P17/00;C12P17/02
Applicant(s) Name: Gist-Brocades NV (NL) Wateringseweg 1, P.O. Box 1, Address:
Inventor(s) Name: Bertola Mauro Attilio;Phillips Gareth Thomas;Rober
Attorney & Agent: ZHANG YUANZHONG WANG JIE
Abstract:
    A process for the preparation of a pharmaceutically active compound in a stereospecific form of the formula (I) or a pharmaceutically acceptable salt thereof, like an acid addition salt, and/or a compound in a stereospecific form of the formula (II) wherein R1 is a heteroaromatic 5 or 6 membered ring containing in addition to carbon atoms, one or more atoms selected from nitrogen, sulphur and oxygen, this ring being optionally substituted, and wherein R2 is an alkyl group of 2 to 6 carbon atoms, compound (III) having at least 80% by weight the S configuration, at least partly separating compound (II) and/or reacting compound (II) with a C2-C6 alkylamine group optionally substituted and at least partly separating compound (I) and/or converting compound (I) into the pharmaceutically acceptable salt thereof.
Time: 6