Title: Process for transforming human insulin precarsor to human insulin
Application Number: 87107019 Application Date: 1987.10.13
Publication Number: 1017963 Publication Date: 1988.04.27
Approval Pub. Date: 1995.06.28 Granted Pub. Date: 1995.06.28
International Classifi-cation: C07K7/40;C12P21/02
Applicant(s) Name: Eli Lilly and Company Address:
Inventor(s) Name: Bruce Hill Frank;Mork Robert Walden;Richard Eugene
Attorney & Agent: YANG JIUCHANG
Abstract:
    This specification describes a process for converting a human insulin precursor having the formula: to human insulin, which comprises treating such human insulin precursor with trypsin and carboxypeptidase B in an aqueous medium containing per mole of human insulin precursor from about 0.1 to about 10 moles of one or more metal ions of those metals having Atomic Numbers 21 to 34, 39 to 52, 57 to 84, and 89 to 92.
Time: 5
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