Title: Synthesizing and screening molecular diversity
Application Number: 94193984 Application Date: 1994.11.02
Publication Number: 1134156 Publication Date: 1996.10.22
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: C07K1/04;C07K1/06;C08F2/06;C12M1/00;C12N15/11;C12Q1/68;G01J1/42;G01N21/62
Applicant(s) Name: Affymax Tech. N.V. Address:
Inventor(s) Name: Jeffrey H. Sugarman;Richard P. Rava;Haim Kedar
Attorney & Agent: WANG DAZUO
Abstract:
    A device and method for efficiently synthesizing diverse molecular products on substrates. A parent vessel (200) contains a suspension of substrates. The suspension is pressurized with argon and transferred to a plurality of reaction vessels (201-209) in one or more reaction vessel banks where monomer addition reactions take place. Optionally, the substrates may be tagged with a tag monomer. A vortexing motor (300) vortexes the contents of reaction vessels (201-209) during monomer addition reactions to enhance synthesis. After the desired monomer and/or tag monomer addition reaction, the suspension is pressurized with argon and transferred back to parent vessel (200) for mixing. Thereafter, the suspension may be pressurized with argon and reallocated among reaction vessels (201-209) for further synthesis.
Time: 9