Title: HIVp-17 peptide fragment, compositions containing and methods for producing and using same
Application Number: 97198681 Application Date: 1997.08.08
Publication Number: 1233187 Publication Date: 1999.10.27
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K38/00;A61K39/21;C07H21/04;C07K1/00;C07K7/00;C07K14/00;C07K17/00;C08H1/00;C09B31/30;C12N15/09;C12
Applicant(s) Name: Viral Technologies, INC. Address:
Inventor(s) Name: D. H. Zimmerman;P. S. Sarin
Attorney & Agent: lu xinhua
Abstract:
    Peptide fragments of the p17 gag protein of HIV-1 from Clade C of from about 30 to about 50 amino acids, including the region extending from position 75 to position 129, raise antibodies recognizing other subtypes, including Clade A, Clade B, Clade E as well as peptides of non-coextensive but overlapping portions of the p17 gag protein. DNA sequences can be used to encode for the peptides of interest. An example of the Clade C peptide of this invention is a peptide having about 30 to about 32 amino acids taken consecutively from a part or the entirety of the following sequence:wherein Xaa at position 4 is Tyr or Trp; Xaa at position 5 is Cys or Ser; Xaa at position 8 is Lys, Glu, or Ala; Xaa at position 9 is Gly, Lys, Asp, Glu, or Arg; Xaa at position 11 is Glu; Xaa at position 12 is Val; Xaa at position 13 is Arg; Xaa at position 21 is Lys; Xaa at position 22 is Ile; Xaa at position 23 is Glu or Lys; Xaa at position 29 is Ile, Ser or Cys; Xaa at position 33 is a direct bond; and Xaa at position 34 is a direct bond.
Time: 4
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