Title: Amino acid loaded trityl alcohol resins, method of producing same and use thereof
Application Number: 200410004866 Application Date: 2004.02.10
Publication Number: 1520827 Publication Date: 2004.08.18
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K31/74,C08G65/48
Applicant(s) Name: Rohm Address:
Inventor(s) Name: Bohling James Charles, Kinzey Marlin Kenneth, Maik
Attorney & Agent: deng yi
Abstract:
     The present invention relates to a process for making a biologically active substance or therapeutic agent free of a chlorotrityl chloride linker-resin. The process includes reacting an activated amino acid or activated amino acid derivative with a substituted or unsubstituted trityl alcohol resin to obtain a resin-CT-AA product; and, reacting the resin-CT-AA product with other building blocks of the biologically active substance or therapeutic agent to obtain said biologically active substance or therapeutic. A product created by this process is also provided herein. The invention is particularly useful to create T-20 and T-1249 therapeutics.
Time: 6