Title: Improved process for preparation of therapeutically useful, crosslinked dextran grain polymers
Application Number: 86103288 Application Date: 1986.05.14
Publication Number: 1005819 Publication Date: 1986.12.17
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K31/715;C08B37/02
Applicant(s) Name: Biogal Gyogyszergyar Address:
Inventor(s) Name: Imre Suto;Janos Erdei;Magdolna Pocs
Attorney & Agent: LIN BAINAN SUN LINGHUA
Abstract:
    A process for preparing therapeutically useful, crosslinked dextran grain polymers and the compositions containing them comprises swelling the crosslinked grain polymer in water at a pH of 1.0 to 5.5, suitably at a pH value of 4.0, while stirring, removing the acidic water and dehydrating by using a water-miscible organic solvent, preferably ethanol, removing the supernatant while stirring, swelling the dehydrated grain polymer in ion-free water, washing it until acid-free, dehydrating and/or drying it, classifying it according to the particle size and formulating it in the form of e.g. a powder, plug or paste, optionally after a sterilization with gamma irradiation. The product is useful for treating, by covering, open wounds.
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