Title: Transfer hydrogenation process and catalyst
Application Number: 01822470 Application Date: 2001.11.29
Publication Number: 1537088 Publication Date: 2004.10.13
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: B01J31/22,C07B53/00,C07C29/143,C07C33/18,C07C33/20,C07C33/46,C07C35/32,C07C41/26,C07C43/178,C07C311/
Applicant(s) Name: Avecia Ltd. Address:
Inventor(s) Name: J.M.J. Williams, C. Bubert
Attorney & Agent: lu xinhua guo anxun
Abstract:
     A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal hydrocarbyl complex which is coordinated to defined bidentate ligands substituted with at least one group selected from an optionally substituted sulphonated hydrocarbyl group, a sulphonated perhalogenated hydrocarbyl group, or an optionally substituted sulphonated heterocyclyl group. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcohols, particularly those comprising chiral centres. The hydrogen donor is advantageously a secondary alcohol or a mixture of triethylamine and formic acid. The process can be employed to transfer hydrogenate ketones and imines, which are preferably prochiral. Catalysts for use in such a process are also provided.
Time: 8
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