Title: Mfr. method and the composition of new peptide-aldehyde compound
Application Number: 85109736 Application Date: 1985.12.19
Publication Number: 1009515 Publication Date: 1987.03.18
Approval Pub. Date: 1994.08.24 Granted Pub. Date: 1994.08.24
International Classifi-cation: A61K37/02;C07K5/08
Applicant(s) Name: Godon. Richard Chemical Industry Inc. Address:
Inventor(s) Name: Daneil. Badi;Eva. Barlabas;Frentz.Zosa;Gijora.Horw
Attorney & Agent: ZHANG YUANZHONG WANG JIE
Abstract:
    The invention relates to new peptide-aldehydes and a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same. According to a feature of the present invention there are provided new peptide-aldehyde derivatives corresponding to the general formula (I) wherein R1 represents hydrogen or C1-6 alkyl group, R2 stands for C1-6 alkyl group, furthermore R1 and R2 are linked to the amino group of the Xxx alpha-amino acid, Xxx represents a D-phenylalanine residue or a D-alpha-amino acid group having in the side chain a C1-4 alkyl group, Pro stands for L-proline residue, Yyy stands for L-, D- or DL-arginine residue and A represents an acid residue. The new peptide-aldehyde derivatives of the invention possess valuable anticoagulant activity.
Time: 5