Title: Process for the preparation of novel peptidase inhibitors
Application Number: 86101268 Application Date: 1986.02.03
Publication Number: 1008285 Publication Date: 1987.02.04
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K31/13;A61K37/02;C07C101/04;C07C103/30;C07K5/00
Applicant(s) Name: Merrell Dow Pharmaceuticals Inc. (US) 2110 East Ga Address:
Inventor(s) Name: Burkhart Joseph P;Gerhart Fritz E;Giroux Eugene L;
Attorney & Agent: TIANG YUE MU DEJUN
Abstract:
    This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.
Time: 8