Title: Process for preparation of novel insulin peptides and novel injectable solutions having prolonged insulin action
Application Number: 86101489 Application Date: 1986.03.11
Publication Number: 1007403 Publication Date: 1987.01.21
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K37/26;C07K7/40
Applicant(s) Name: Novo Industri A/S (DK) Novo Alle, 2880 Bagsuacrd, Address:
Inventor(s) Name: Jan Markussen
Attorney & Agent: XIN MINZHONG GU BAIDI
Abstract:
    Insulin derivatives having a charge which is positive compared with the charge of human insulin at neutral pH, can be used to prepare solutions having prolonged insulin action. In the novel insulin derivatives, a basic amino acid has been substituted in the B27-position and/or a neutral amino acid has been inserted in the A4-, A17-, B13- and/or B21-position. Furthermore, the C-terminal carboxyl group of the B-chain may be blocked with an amido or ester residue.
Time: 4