Title: Method for selectively increasing the ratio of single major components of teicoplanin A2 complex
Application Number: 86103528 Application Date: 1986.05.21
Publication Number: 1005211 Publication Date: 1986.11.26
Approval Pub. Date: 1995.07.12 Granted Pub. Date: 1995.07.12
International Classifi-cation: C07K4/00;C12P1/06;C12P21/06
Applicant(s) Name: Gruppo Lepetit S.P.A. (IT) Via Roberto Lepetit 8, Address:
Inventor(s) Name: Anacleto Gianantonio;Francesco ASSI;Giancarlo Lanc
Attorney & Agent: WANG SUNJIA
Abstract:
    The object of this invention is to provide a method for selectively increasing the ratio of the single T-A2 major components in the T-A2 complex. More particularly, the object of this invention is a process for obtaining teicoplanin A2 selectively enriched in any of its major components, T-A2-1, T-A2-2, T-A2-3, T-A2-4 and T-A2-5 which consists in adding to the culture medium of Actinoplanes teichomyceticus nov. sp. ATCC 31121 or a mutant thereof which produces T-A2 complex through the same metabolic pathway, a selectively effective amount of an appropriate precursor.
Time: 4