Title: Process for preparing water soluble xanthylium derivative substrates and uses thereof
Application Number: 86103598 Application Date: 1986.05.26
Publication Number: 1008939 Publication Date: 1987.02.25
Approval Pub. Date: 1995.02.08 Granted Pub. Date: 1995.02.08
International Classifi-cation: C07K5/10
Applicant(s) Name: Coulter Electronies Inc. (US) 590 West 20th Street Address:
Inventor(s) Name: Gary A. Mitchell;Gerald E. Jaffe;Marilyn M. Solorz
Attorney & Agent: TIANG YUE MU DEJUN
Abstract:
    Water soluble xanthylium derivative substrates of rhodamine 110 and rhodol permit spectrophotometric and fluorescent measurements of trypsin-like enzymes without the addition of organic solvent additives and/or special water solubilizing agents. These novel substrates exhibit increased sensitivity for determining low levels of activity of trypsin-like enzymes such as proteolytic enzymes, cofactors, activators, antiactivators, and inhibitors. These substrates can be substituted for fibrinogen to monitor the pathways of blood coagulation.
Time: 4