Title: Selective chemical removal of protein amino-terminal residue
Application Number: 86107569 Application Date: 1986.10.28
Publication Number: 1011968 Publication Date: 1987.07.08
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: C07K7/26;C07K7/40;C07K15/26
Applicant(s) Name: Eli Lilly and Co. (US) Lilly Corporate Center, Ind Address:
Inventor(s) Name: Gerald Stephen Brooke;Richard Dennis Dimarchi
Attorney & Agent: WANG WEI
Abstract:
    The invention relates to a process for producing a compound having an amino acid sequence defining a biologically active peptide or protein from a compound of the formula H-X-Pro-Peptide in which X is the residue of a naturally occurring amino acid and Peptide is a sequence of amino acids defining a biologically active peptide or protein, which comprises subjecting H-X-Pro-Peptide to conditions under which a diketopiperazine of the H-X-pro- moiety is formed with accompanying cleavage and release of Peptide.
Time: 10