Title: Method for producing hepatitis B virus proteins in yeast
Application Number: 87100465 Application Date: 1987.01.28
Publication Number: 1013911 Publication Date: 1987.10.14
Approval Pub. Date: 1996.07.17 Granted Pub. Date: 1996.07.17
International Classifi-cation: A61K38/02;A61K39/29;C07K14/02;C12N15/51;C12P21/02
Applicant(s) Name: Merck Address:
Inventor(s) Name: Arpi Hagopian;Peter.J. Kniskern;Ronald.W.Ellis
Attorney & Agent: XIA XIAO
Abstract:
    The entire hepatitits B virus pre-S antigen gene linked in one contiguous reading frame to the hepatitis B virus surface antigen gene has been expressed in Saccharomyces cerevisiae. The expressed protein aggregates into a particulate form which displays the major antigenic sites encoded by both domains, thereby highlighting the utility of yeast as a host for the expression of pre-S domains. This protein is useful in in vitro diagnostic systems and as a vaccine for the treatment and prevention of hepatitis B virus-induced diseases and/or infections.
Time: 4
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