Title: Alpha interferon analogue
Application Number: 87102497 Application Date: 1987.03.30
Publication Number: 1014543 Publication Date: 1987.11.11
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K45/02;C07K15/26;C12N15/00;C12P21/02
Applicant(s) Name: Interferon Sciences Inc. (US) 783 Jersey Avenue Ne Address:
Inventor(s) Name: John T. O
Attorney & Agent: CAO HENGXING LIN YUZHEN
Abstract:
    A novel alpha interferon analogue, lacking a diaminopeptidase site at positions 22-23, may be expressed intact in hosts whose primary proteolytic activity against the natural species is at that site. A preferred host is a Saccharomyces cerevisiae strain carrying the PEP 3-4 mutation. The analogue has a Ser, Thr, Asn, Gln or Gly at position 22.
Time: 10