Title: HTLV-3/LAV virus related peptides, antibodies to the peptides, vaccines, passive and active immunization against aids virus
Application Number: 87103568 Application Date: 1987.05.18
Publication Number: 1016029 Publication Date: 1988.01.27
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K39/385;A61K39/395;C07K7/48;G01N33/534;G01N33/535
Applicant(s) Name: Viral Technologies, Inc. (US) 777 14th Street, N.W Address:
Inventor(s) Name: Allan L. Goldstein;Su Sun Wang
Attorney & Agent: GU BAIDI XIN MINZHONG
Abstract:
    Vaccines effective in the inhibition of infection caused by the family of retroviruses, HTLV-III, Human T-cell Leukemia Virus, LAV, Lymphadenopathy-associated virus, ARV-2, AIDS-Related Virus, (AIDS and AIDS-Related Complex) have been developed from an antisera prepared against thymosin alpha 1 (T alpha 1), a thymic hormone, as well as from antisera to synthetic peptide fragments of T alpha 1 and antisera to synthetic peptide fragments inclusive of amino acid positions 92-109 of the p17 gag core protein of HTLV-III, LAV and ARV-2. Immunoglobulin (IgC)-enriched preparations of the T alpha 1 antisera have enhanced activity in blocking viral replication. A diagnostic test capable of directly detecting the presence of HTLV-III, LAV, ARV-2 and related retroviruses associated with AIDS and ARC is also described.
Time: 8
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