Title: Glycopeptide decovery process
Application Number: 88101111 Application Date: 1988.02.27
Publication Number: 1021709 Publication Date: 1988.10.26
Approval Pub. Date: 1996.07.31 Granted Pub. Date: 1996.07.31
International Classifi-cation: A61K38/14;C07K1/18;C07K9/00
Applicant(s) Name: Eli Lilly and Co. (US) Indiana, America Address:
Inventor(s) Name: Charles William Johnson;John Lawrence Spencer;Suza
Attorney & Agent: CAO HENGXING
Abstract:
    A process for recovering vancomycin-type glycopeptide antibiotics which comprises 1) commingling the fermentation medium in which the antibiotic is produced with a polystyrene divinylbenzene resin such as Dow XFS-43278.00, 2) separating the resin from the medium and 3) eluting the antibiotic from the resin. This improvement avoids preliminary filtration and pH adjustment of the broth, simplifies waste-disposal problems and eliminates antibiotic losses due to mycelial adsorption and filtration.
Time: 8
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