Title: Crystalline human proinsulin and process for its production
Application Number: 88102311 Application Date: 1988.04.20
Publication Number: 1022000 Publication Date: 1988.11.09
Approval Pub. Date: 1996.02.14 Granted Pub. Date: 1996.02.14
International Classifi-cation: C07K1/00;C07K14/62
Applicant(s) Name: Eli Lilly and Co. (US) Lilly Corporate Center, Cit Address:
Inventor(s) Name: Eddie Herman;Massey;Richard Lee Jackson
Attorney & Agent: LIN YUZHEN
Abstract:
    The present invention relates to crystalline human proinsulin and process for its production. The preparation comprises (a) preparing an aqueous mixture containing from about 5 to about 50 mg/ml human proinsulin, from about 0.1 to about 5 mg/ml of a phenolic substance, from about 0.03 to about 0.6 milliequivalents/ml of a salt of a cation selected from the group consisting of lithium, calcium, sodium, potassium, ammonium, magnesium, and barium, and from about 0.2 to about 5 milliequivalents of Zn
Time: 6
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