Title: 1,5 benzodiazepine derivatives having CCK and/or gastrin antagonistic activity
Application Number: 94191771 Application Date: 1994.04.13
Publication Number: 1120845 Publication Date: 1996.04.17
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K38/05;C07K5/06
Applicant(s) Name: Glaxo Inc. Address:
Inventor(s) Name: Harry Finch;Pritom Shah;Robin Arthur Carr
Attorney & Agent: GUAN LIXIN LUO CAIXI
Abstract:
    The present invention relates to compounds of general formula (I) and physiologically acceptable salts thereof wherein the group NR1R2 represents a 5-7 membered saturated heterocyclic ring which may be substituted by one or two methyl groups; R3 is C1-6alkyl, C3-6cycloalkyl or phenyl optionally substituted by 1 or 2 halogen atoms; R4 is phenyl or phenyl substituted by one or two groups selected from the group consisting of halogen, C1-4alkyl, trifluoromethyl, trifluoromethoxy or (CH2)nR5 wherein n is zero or 1 and R5 represents C1-4alkoxy, hydroxy, nitro, cyano, CO2R6, S(O)pCH3, NR7R8, CONR7R8, SO2NR7CO(C1-4)alkyl, tetrazolyl, carboxamidotetrazolyl, or a 3-trifluoromethyl 1,2,4-triazolyl; R6 is hydrogen, C1-4alkyl or benzyl; R7 is hydrogen or C1-4alkyl, R8 is hydrogen, C1-4alkyl, SO2CH3 or SO2CF3, X represent hydrogen, C1-4alkyl or halogen; m is zero, 1 or 2, and p is zero, 1 or 2.
Time: 8
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