Title: Synthesis, products and its application for luleinizing hormone releasing hormone and antagonistic znalogue
Application Number: 90108955 Application Date: 1990.11.10
Publication Number: 1061605 Publication Date: 1992.06.03
Approval Pub. Date: Granted Pub. Date: 1997.11.05
International Classifi-cation: A61K38/09,C07K7/23
Applicant(s) Name: Birth Control Institute, Tianjing City Address: 300191
Inventor(s) Name:
Attorney & Agent: HE RUNHUA HU WANHUA
Abstract:
     The invention belongs to the compostion method products and application of peptide which contains 5-100 chain element whole definite amino acid and its derivatives. The invention takes NAC-D2NaL 1, DPCL DPCLPhe 2, D3Pal 3, Ser 4, Tyr 5 DArg 6, Leu 7, Arg 8, Pro 9, DAla 10] NH2 as parent element and transtorms the alkali zone and lipophilic zone mdecular to obtain the general formula of compound matter of NAC-D2Nal 1}, AA 2, AA 3, Ser 4, AA 5, AA 6, Leu 7, AA8, Pro 9, DAla 10 ] NH2. The invention can lower HRA at the same time of keeping high AOA, and can be used as a kind of peptidic medicine to cure the diseases of genital endocrine system disorder and use on birth control.
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