Title: Peptides
Application Number: 93105500 Application Date: 1993.05.03
Publication Number: 1094730 Publication Date: 1994.11.09
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K37/02,C07K5/04
Applicant(s) Name: Sandoz Ltd. Address:
Inventor(s) Name: Richard Heng, Trevor Glyn Payne
Attorney & Agent: QI ZENGDU
Abstract:
     The peptides compounds in the free or salt form with pharmacological activity e.g. IL-1 beta release inhibition, include di-, tri- and tetra-peptides, Wherein final alpha-amino acid is based on aspartic acid and has a residue, which may be H, CF3, -Z1-Z2-Y2 (where Z1 and Z2 are respectively direct bond or alpha-amino acid residue and Y2 is NH2, C1-4 alkylamino, bis-(c1-4 alkyl) amino or heterocyclic radical), -CH2-X1-Y3 (where X1 is O or S and Y3 is heteroaryl), -CH2-Y3, substituted phenyl, ring-substituted phenoxymethylene or benzenethiomethylene, ring-substituted pyridinoxymethylene, or -CH2-X1-CO-Y4 (where X1 is O or S and Y4 is trialkylmethyl or substituted phenyl or pyridyl).
Time: 5
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