Title: Crystals of a vitamin D derivative and a method for the preparation thereof
Application Number: 200410092617 Application Date: 1997.06.16
Publication Number: 1637017 Publication Date: 2005.07.13
Approval Pub. Date: 2006.09.27 Granted Pub. Date: 2006.09.27
International Classifi-cation: C07J9/00;C07C401/00;C07C43/188
Applicant(s) Name: Chugai Pharmaceutical Co., Ltd. Address:
Inventor(s) Name: Yamauchi Tsuyoshi
Attorney & Agent: li huayang
Abstract:
    The present invention provides crystals of the compound represented by formula (I): crystals of a vitamin D derivative which are obtained by purifying a crude or preliminarily purified product of the vitamin D derivative through a reverse phase chromatography and then crystallizing the purified derivative from an organic solvent; novel compounds which are formed during the synthesis of a vitamin D derivative as by-product; and a method for purifying a vitamin D derivative or the precursor thereof. The method of the present invention makes it possible to supply a highly purified vitamin D derivative, especially ED-71, in bulk and steadily.
Time: 12