Title: 16-hydroxyestratrienes as selective estrogens
Application Number: 00803613 Application Date: 2000.02.09
Publication Number: 1346364 Publication Date: 2002.04.24
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K31/565;C07J1/00;C07J15/00;C07J31/00;C07J33/00;C07J41/00;C07J53/00
Applicant(s) Name: Schering AG Address:
Inventor(s) Name: Hermann Kinzer;Rudolf Knauthe;Monika Lessel
Attorney & Agent: guo xiaodong
Abstract:
    The invention relates to novel compounds as pharmaceutical agents which have in vitro a higher affinity to estrogen receptor preparations of the rat prostate than to estrogen receptor preparations of the rat uterus and which preferably have in vivo a preferential effect on bones as compared to the uterus and/or a marked effect with regard to the stimulation of the expression of the 5HT2a receptor and transporter. The invention also relates to the production and to the use in therapy of these compounds and to pharmaceutical administration forms containing said novel compounds. The novel compounds are 16 alpha and 16 beta hydroxy-estra,1,3,5(10)-estratriene which carry additional substituents at the steroid backbone and one or more additional double bonds on the B, C and/or D rings.
Time: 9