Title: Synthesis of poly glycol monomethyl ether cholesterol succinate derivative and its preparation
Application Number: 00110157 Application Date: 2000.03.01
Publication Number: 1311189 Publication Date: 2001.09.05
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K9/127,A61K9/50,A61K31/765,C07J9/00,C08F261/00
Applicant(s) Name: Shenyang Pharmacy Univ. Address: 110015
Inventor(s) Name: Deng Yihui, Li Huanqiu
Attorney & Agent: li yutong
Abstract:
     This invention is a synthesis of polyglycol monomethyl ether cholesterol succinate derivative and its preparation; it can coat the lipoid, emulsion and micro m capsule (granule), prolong thier invo half-life period and circulating period in blood, and improve the physical stability of the preparation. It is made up by using succinic anhydride and cholesterol as raw-materials through reflux reaction, and its structural formala is as the above diagram where n=10-200. This invention is simple in technology and easy for realization.
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