Title: Orally active androgens
Application Number: 00810310 Application Date: 2000.07.10
Publication Number: 1360589 Publication Date: 2002.07.24
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K31/565;A61P5/26;C07J1/00
Applicant(s) Name: Akzo Nobel N.V. Address:
Inventor(s) Name: H.J.J. Loozen;D. Leysen;J. Van Der Louw
Attorney & Agent: cheng jinshan
Abstract:
    Novel, orally active androgens are 7alpha-substituted DELTA14-nandrolone derivatives. The compounds satisfy the general formula (1): wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6) alkyl, or (C1-6) acyl; R2 is selected from the group consisting of (C2-4) alkyl, (C2-4) alkenyl, or (C2-4) alkynyl, each optionally substituted by halogen; or R2 is cyclopropyl, or cyclopropenyl, each optionally substituted by (C1-2) alkyl, or halogen; R3 is hydrogen, (C1-2) alkyl, or ethenyl; R4 is (C1-2) alkyl; R5 is hydrogen, or (C1-15) acyl; and the dotted lines indicate optional bonds.
Time: 8