Title: Improved process for preparing macrolide derivatives
Application Number: 87102397 Application Date: 1987.03.27
Publication Number: 1013732 Publication Date: 1987.10.07
Approval Pub. Date: 1993.07.21 Granted Pub. Date: 1993.07.21
International Classifi-cation: A61K31/70;C07H17/08
Applicant(s) Name: Eli Lilly and Co. Address:
Inventor(s) Name: Eddie Vi-ping Tao;Jeffrey Thomas Vicenzi
Attorney & Agent: MA CHONGDE
Abstract:
    This invention provides an improvement in the process for preparing C-20-amino-substituted derivatives of the macrolide antibiotics of the tylosin type by reductively aminating the C-20 aldehyde group in the parent antibiotic. The improvement comprises using formic acid as the reducing agent. The new process is less expensive and more amenable to scale-up than previously used processes, but is still selective.
Time: 4