Title: Process for obtaining chemically defined and reproducible polydeoxy-ribonucleotide
Application Number: 87103688 Application Date: 1987.04.17
Publication Number: 1015889 Publication Date: 1988.01.20
Approval Pub. Date: 1993.07.14 Granted Pub. Date: 1993.07.14
International Classifi-cation: C07H1/08;C07H21/04
Applicant(s) Name: Crinos Industria Farmacobiologica Spa Address:
Inventor(s) Name: Gianfranco Fedeli;Giuseppe Diamantini;Marisa Manto
Attorney & Agent: LI YING
Abstract:
    By carrying out the depolymerization of stabilized solutions of highly polymerized and nicked polydeoxyribonucleotides, as obtained through stabilizing aggregation of raw nucleic acids, the depolymerization being carried out by heating at controlled temperature and being controlled as a function of the variation of the reversible hyperchromicity, followed by the removal of the hydrogen bonds in the double stranded filaments and by thermal stabilization of the single stranded filaments, the polydeoxyribonucleotide, known as Defibrotide is obtained. Defibrotide has well defined chemico-physical properties, reproducible in the industrial production.
Time: 4
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