Title: Cytorhodin S derivatives, a process for their preparation and their use as medicaments
Application Number: 87104384 Application Date: 1987.06.24
Publication Number: 1015757 Publication Date: 1988.01.13
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K31/70;C07H19/01
Applicant(s) Name: Hoechst Japan Ltd. (JP) 10-16, 8-Chome, Akasaka Mi Address:
Inventor(s) Name: Etsuko Ohkouchi;Hiroshi Kitagawa;Toshiro Iwahashi;
Attorney & Agent: MU DEJUN FAN WEIMIN
Abstract:
    Cytorhodin S derivatives, especially cytorhodin S-immunoglobulin complexes are disclosed. Cytorhodin S itself possesses very high anticancer activity, but the complexes act more selectively on cancer cells and are more useful as an anticancer agent. In order to produce cytorhodin S-immunoglobulin complexes, the oxo group on saccharide chain of cytorhodin S is reduced with an alkali metal cyanoborohydride in the presence of an ammonium salt or a compound having amino group to be converted to amino group or substituted amino group. Then, thus produced cytorhodin S derivatives are bound to immunoglobulin by means of a bifunctional cross-linking agent, a condensing agent or a spacer.
Time: 4
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