Title: N-acetyl-3-fluoro-neuraminic acid derivatives and preparation thereof
Application Number: 88101146 Application Date: 1988.03.06
Publication Number: 1020919 Publication Date: 1988.09.21
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: C07H5/06;C07H15/04
Applicant(s) Name: Mect Corp. (JP) 2-1-1, Nishi-Shin Address:
Inventor(s) Name: Hiroshi Meguro;Hiroshi Ohrui;Tatsuo Ido
Attorney & Agent: TIANG YUE
Abstract:
    This invention relates to novel derivatives of N-acetyl-3-fluoro-neurminic acid derivatives (I) and preparation thereof. The compound (I) can be synthesized by reacting a solution of alkyl 5-acetamido-2,6-anhydro-4,7,8,9-tetra- O-acetyl-2,3,5-trideoxy-D-glycero-D-galacto-2-enonate with (i) an inert gas containing fluorine or (ii) acetylhypofluorite obtained by passing the inert gas containing fluorine through a mixture of acetic acid/acetate by passing thereinto, and then removing a solvent and applying the residue through a silica gel column chromatography.
Time: 9