Title: Alkaloids from mappia foetida, the use thereof and formulations containing them
Application Number: 94114908 Application Date: 1994.07.30
Publication Number: 1121075 Publication Date: 1996.04.24
Approval Pub. Date: 2000.05.10 Granted Pub. Date: 2000.05.10
International Classifi-cation: A61K31/47;C07D471/14;C07G5/00
Applicant(s) Name: Indena S.P.A. Address:
Inventor(s) Name: Ezio Bombardelli;Giuseppe Mustich;Luisella Verotta
Attorney & Agent: TIANG WEIJIE
Abstract:
    The present invention relates to novel alkaloids from Mappia foetida, foetidine 1 and 2, having anticancer and antiviral properties. These alkaloids, soluble in water, are present in all the parts of the plant, and are the precursors of camptothecin and of 9-methoxy-camptothecin, which are alkaloids known to have pharmacodynamic properties but also to be insoluble in water. The particular water solubility of the novel compounds make them particularly suitable for the treatment of the patients by the parenteral route, avoiding the use of toxic excipients or of unsuitable chemical derivatizations.
Time: 6