Title: Process for the prepn. of an agetidine-3-carboxylic acid or salt thereof
Application Number: 86106702 Application Date: 1986.09.29
Publication Number: 1009899 Publication Date: 1987.04.01
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: C07D205/04;C07F1/00;C07F3/00
Applicant(s) Name: Shell Internationale Research Maatschappij B.V. (N Address:
Inventor(s) Name: Gerhard DE Lind Van Wijngaarden;Jannetje DE Waal;P
Attorney & Agent: ZHANG YUANZHONG WANG JIE
Abstract:
    The invention relates to a process for the preparation of an azetidine-3-carboxylic acid of the formula I or a salt thereof, wherein R1 represents a hydrogen atom, a C1-6 alkyl or C3-8 cycloalkyl group or a group phenyl-CH(R3)- wherein R3 represents a hydrogen atom, a phenyl or an alkyl group of 1-4 carbon atoms, which process comprises reacting an azetidine of the formula II wherein R1 has the meanings defined above, and X represents a hydrogen atom, a carboxyl or a group, with an alkali metal base at a temperature of from 150 to 300 DEG C in the presence of a catalyst comprising a metal of the Group IIB of the Periodic System and/or a compound of said metal, and if desired converting the obtained azetidine-3-carboxylic acid salt into the corresponding acid; and to novel alkali, alkaline earth and quaternary ammonium salts of such acids.
Time: 4